The Test for Hypoallergenicity of Skin MD Natural

Cantor Research Laboratories, Inc.



50 HUMAN SUBJECT REPEAT INSULT PATCH TEST
SKIN IRRITATION/SENSITIZATION EVALUATION
(OCCLUSIVE PATCH)

The standard guidelines recognized in the industry for Repeat Insult Patch Test involves placing an occlusive patch, which is sealed on all four sides, on an one inch area of skin. This clinical study was conducted using Skin MD Natural on 50 consenting women panelists. The patches are left on for 24 hours. The following day they come back to the lab for an evaluation and another patch is placed on the same area. This process is repeated for nine applications, after which a 10-14 day rest period is given. Each panelist then comes back for a "challenge test" which is done on an adjacent unexposed area of skin. They return to the lab 24 hours later when the patch is removed and evaluated. This is again repeated.

Skin MD Natural did not produce any reaction or sensitivity during the entire trial period on any of the 50 women tested. These clinical trials gives Skin MD Natural the highest hypoallergenic and "safe use" rating.

July 29, 2005

RIPT.C0608-A.O.50.GLO.SUMM